This book explores the convergence of cloud computing, artificial intelligence, and Big Data, examining their foundations, applications, and synergies. It covers 17 chapters detailing the interplay of these next-generation paradigms and their hybrid blend with IoT. The text discusses recent advancements, applications, and challenges in areas such as security, latency, energy consumption, and healthcare services. It provides a comprehensive overview of state-of-the-art applications, proposed solutions, and framework enhancements. The book is aimed at researchers, postgraduate students, and professionals in computing, software engineering, electrical engineering, data analysis, and cybersecurity.